General Information of Synthetic Binding Protein (SBP) (ID: SBP001517)
SBP Name
Fab anti-Ars-Tyr/DNA Arg-Arg VH mutant
Synonyms
Fab Arg-Arg VH mutant
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli XL1-Blue
Selection Method Phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
DNA
BTS Info
Binder Diagnostic reagent; Therapeutic application N.A. Thomas Jefferson Medical College [1]
Azophenylarsonate-N-acetyl-L-tyrosine
BTS Info
Binder Diagnostic reagent; Therapeutic application N.A. Thomas Jefferson Medical College [1]
References
1 Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. J Exp Med. 1995 Sep 1;182(3):743-50.