General Information of Synthetic Binding Protein (SBP) (ID: SBP001510)
SBP Name
Fab anti-CD98 A18
Synonyms
Fab A18
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display
Highest Status Research
SBP Sequence
>Heavy Chain
QVKLLESGGGLVQPSQSLSITCTVSGFSLTTYGLHWVRQPPGKGLEWLGVIWSNGRIDYN
AAFISRLSITKINSKSQVFFKHNSLQDDDTAIYYCARNVYDSLTWFTYWGQGTLVTVSA
>Light Chain
DIQMTQTPSSLAVSVGEKVIMSCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTR
ESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPPTFGGGTKLEIKRA
Template Name HBJ127
Template Sequence
>Heavy Chain
QVKLLESGPGLVQPSQSLSITCTVSGFSLTTYGLHWVRQPPGKGLEWLGVIWSNGRIDYN
AAFISRLSITKINSKSQVFFKHNSLQDDDTAIYYCARNVYDSLTWFTY WGQGTLVTVSA
>Light Chain
DIQMTQSPSSLAVSVGEKVIMICKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIFWASTR
ESGVPDRFTGSGSGTDFPLTISSVKAEDLAVYFCQQYYIYPPTFGGGTKLEIKRA
Protein Scaffold Information of This SBP
Scaffold ID PS034
Scaffold Info
[1]
Scaffold Name Fab
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
4F2 cell-surface antigen heavy chain
BTS Info
Binder Tumors [ICD-11: XH1N44] N.A. University of Shizuoka [1]
References
1 Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization. Cancer Sci. 2014 Apr;105(4):396-401.