General Information of Synthetic Binding Protein (SBP) (ID: SBP001326)
SBP Name
Monobody anti-c-Src 1C9
Synonyms
Monobody 1C9
Molecular Weight 9.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Phage display
Highest Status Research
Sequence Length 90
SBP Sequence
>Monobody anti-c-Src 1C9
VSDVPRDLEVVAATPTSLLISWDAPSGPLDYYRITYGETGGNSPVQEFTVPGSKSTATIS
GLKPGVDYTITVYAYSLSPPSKPISINYRT
3D Structure
Computationally Modelled Structure
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Template Name Fibronectin type III domain (FN3)
Protein Scaffold Information of This SBP
Scaffold ID PS047
Scaffold Info
[1]
Scaffold Name Monobody
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Proto-oncogene tyrosine-protein kinase Src
BTS Info
Binder Research tool Kd: 1300 nM Biosciences Division [1]
References
1 Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain. Chem Biol. 2004 Jun;11(6):835-44.