Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001082) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Nanobody anti-GABA(A) beta3 clone 25
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| Synonyms |
Nb25
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| Molecular Weight | 13.7 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli WK6 | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| PDB ID | 5OJM | |||||
| Sequence Length | 125 | |||||
| SBP Sequence |
>Nanobody anti-GABA(A) beta3 clone 25
QVQLQESGGGLVQAGGSLRLSCAASGHTFNYPIMGWFRQAPGKEREFVGAISWSGGSTSY ADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYCAAKGRYSGGLYYPTNYDYWGQGTQ VTVSS |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS048 | [1] | ||||
| Scaffold Name | Nanobody | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta-3 | Binder | Acute and chronic anxiety [ICD-11: MB24.3] | N.A. | University of Oxford | [1] | |