Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP000550) | ||||||
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SBP Name |
Knottin anti-Integrin 7A
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Synonyms |
Knottin 7A
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Molecular Weight | 4.1 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Pichia pastoris | |||||
Selection Method | Yeast display | |||||
Highest Status | Research | |||||
Sequence Length | 38 | |||||
SBP Sequence |
>Knottin anti-Integrin 7A
GCVRLHESCLGQQVPCCDPAATCYCSGRGDNDLVCYCR |
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Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VIII form disulfide bonds; Cys VI and Cys VII form disulfide bonds. | |||||
3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | AgRP | |||||
Template Sequence Description | Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VIII form disulfide bonds; Cys VI and Cys VII form disulfide bonds. | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS042 | [1] | ||||
Scaffold Name | Knottin | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Integrin alpha-v-beta-3 | Binder | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Kd: 0.78 nM | Stanford University | [1] | |