Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000537)
SBP Name	Knottin anti-Integrin AgTx 7C
Synonyms	Knottin AgTx 7C
Molecular Weight	4.2 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research
Sequence Length	38
SBP Sequence	>Knottin anti-Integrin AgTx 7C GCIAEDYGRCTWGGTPCCRGRPCRCYGRGDNDLRCECT
Sequence Description	Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VIII form disulfide bonds; Cys VI and Cys VII form disulfide bonds.
3D Structure
	Computationally Modelled Structure
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Template Name	AgTx
Template Sequence Description	Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VIII form disulfide bonds; Cys VI and Cys VII form disulfide bonds.

Protein Scaffold Information of This SBP
Scaffold ID	PS042 Scaffold Info					[1]
Scaffold Name	Knottin
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Integrin alpha-v-beta-3	BTS Info	Binder	Imaging agent	N.A.	Stanford University	[1]

References

1

Engineering agatoxin, a cystine-knot peptide from spider venom, as a molecular probe for in vivo tumor imaging. PLoS One. 2013;8(4):e60498.