Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000519)
SBP Name
Knottin anti-NRP1 N2.6
Synonyms
Knottin N2.6
Molecular Weight 3.2 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Bacteria display
Highest Status Research
Sequence Length 29
SBP Sequence
>Knottin anti-NRP1 N2.6
GTCRTLGCTCLPLRCKAPRMVRCGETCWG
Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
3D Structure
Computationally Modelled Structure
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Template Name Kalata B1
Template Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
Protein Scaffold Information of This SBP
Scaffold ID PS042
Scaffold Info
[1]
Scaffold Name Knottin
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Neuropilin-1
BTS Info
Antagonist Cancers [ICD-11: 2D4Z] Kd: 34 nM University of California [1]
References
1 Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration. ACS Chem Biol. 2013;8(6):1147-54.