General Information of Synthetic Binding Protein (SBP) (ID: SBP000297)
SBP Name
Macrocyclic peptide anti-C5 RA-101295
Synonyms
Macrocyclic peptide RA-101295
Molecular Weight 2 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Complement C5
BTS Info
Inhibitor Sepsis [ICD-11: 1G40-1G41] N.A. Ra Pharmaceuticals [1]
References
1 Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6390-E6399.