Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000290)
SBP Name
Macrocyclic peptide anti-Integrin P5
Synonyms
Macrocyclic peptide P5
Molecular Weight 0.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Sequence Length 6
SBP Sequence
>Macrocyclic peptide anti-Integrin P5
RGD[d-Phe][N(Me)V]
Sequence Description Arg and Val form a bridge; [N(Me)V] represents N-methylated valine.
Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1] , [2]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Integrin alpha-v-beta-3
BTS Info
Antagonist Cancers [ICD-11: 2D4Z] N.A. Massachusetts General Hospital [1] , [2]
References
1 Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002 Apr 5;296(5565):151-5.
2 N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40.