General Information of Synthetic Binding Protein (SBP) (ID: SBP000283)
SBP Name
Macrocyclic peptide anti-CmABCB1 aCAP
Synonyms
Macrocyclic peptide aCAP
Molecular Weight 2.1 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
PDB ID 3WMG
Sequence Length 18
SBP Sequence
>Macrocyclic peptide anti-CmABCB1 aCAP
[d-Trp]LDQIVWFNAPGDLHLCG
Sequence Description Ac and Cys form a bridge.
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Cyanidioschyzon merolae ABC transporter
BTS Info
Inhibitor Tools as cocrystallization ligands of selenomethionine-labeled PfMATE N.A. The University of Tokyo [1]
References
1 Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4049-54.