Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000273)
SBP Name	Macrocyclic peptide anti-E6AP CM11-1S-1
Synonyms	Macrocyclic peptide CM11-1S-1
Molecular Weight	1.6 kDa
Design Method	de novo protein design
Expression System	FIT system
Selection Method	mRNA display
Highest Status	Research
Sequence Length	14
SBP Sequence	>Macrocyclic peptide anti-E6AP CM11-1S-1 [d-Trp]SDV[MeS]GR[MeF][MeG]Y[MeF]PCG
Sequence Description	Ac and Cys form a bridge; [MeS] represents N-methylserine; [MeF] represents N-methylphenylalanine; [MeG] represents N-methylglycine.

Protein Scaffold Information of This SBP
Scaffold ID	PS044 Scaffold Info					[1]
Scaffold Name	Macrocyclic peptide
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Ubiquitin-protein ligase E3A	BTS Info	Binder	Human papillomaviruse infection(HPV16)	Kd: 11.7 nM	The University of Tokyo	[1]

References

1

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library. Chem Biol. 2011 Dec 23;18(12):1562-70.