General Information of Synthetic Binding Protein (SBP) (ID: SBP000270)
SBP Name
Macrocyclic peptide anti-HSA p1
Synonyms
Macrocyclic peptide p1
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Transcription-translation coupled with association of PuL display
Highest Status Research
Sequence Length 10
SBP Sequence
>Macrocyclic peptide anti-HSA p1
XTYNERLFWC
Sequence Description X represents N-[3-(2-chloroacetamido)benzoyl]-l-Phe (ClAB-l-Phe); The chloroacetyl and thiol groups form a bridge via a thioether linkage.
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Albumin
BTS Info
Binder Research tool Kd: 41 nM The University of Tokyo [1]
References
1 TRAP display: a high-speed selection method for the generation of functional polypeptides. J Am Chem Soc. 2013 Apr 10;135(14):5433-40.