Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000147) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
BiTE AMG-562
|
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| Synonyms |
AMG562
|
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| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase I | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS018 | [1] , [2] | ||||
| Scaffold Name | BiTE | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| T-cell surface glycoprotein CD3 | Binder | B-cell non-hodgkin lymphoma [ICD-11: 2B33.5]; Follicular lymphoma [ICD-11: 2A80]; Mantle cell lymphoma [ICD-11: 2A85.5] | N.A. | Amgen | [1] , [2] | |
| B-lymphocyte antigen CD19 | Modulator | B-cell non-hodgkin lymphoma [ICD-11: 2B33.5]; Follicular lymphoma [ICD-11: 2A80]; Mantle cell lymphoma [ICD-11: 2A85.5] | N.A. | Amgen | [1] , [2] | |
| Clinical Trial Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| NCT03571828 | Click to show the Detail | |||||
| Indication | Relapsed or Refractory Diffuse Large B-cell Lymphoma; Mantle Cell Lymphoma; Follicular Lymphoma | |||||
| Phase | Phase I | |||||
| Title | A Phase I, First-in-Human, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of?AMG 562?in Subjects With Relapsed / Refractory Diffuse Large B-cell Lymphoma, Mantle Cell Lymphoma, or Follicular Lymphoma | |||||
| Status | Active, not recruiting | |||||
| Sponsor | Amgen | |||||