Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000004)
SBP Name	Monobody anti-IGF-1R AT58oPeg4o
Synonyms	AT58oPeg4o
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS047 Scaffold Info					[1] , [2]
Scaffold Name	Monobody
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Insulin-like growth factor 1 receptor	BTS Info	Inhibitor	Tumors [ICD-11: XH1N44]	Kd: 0.11 nM	Bristol-Myers Squibb Research & Development	[1] , [2]

References

1	Anti-VEGFR2 and anti-IGF-1R-Adnectins inhibit Ewing's sarcoma A673-xenograft growth and normalize tumor vascular architecture.Angiogenesis. 2012 Dec;15(4):685-95.
2	A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor. MAbs. Jan-Feb 2011;3(1):38-48.