General Information of Binding Target of SBP (BTS) (ID: ST00605)
BTS Name
Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10
BTS Type
Protein
Family
Alpha-9/CHRNA9 sub-subfamily;
Alpha-10/CHRNA10 sub-subfamily
Organism
Rattus norvegicus (Rat)
UniProt ID
P43144, Q9JLB5
UniProt Entry
ACHA9_RAT, ACH10_RAT
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Knottin anti-nAChR Ms11a-4 Research Inhibitor IC50: 202 nM Tools for binding to distinct subtypes of nAChRs as well as to inhibit their function
SBP Info
[1]
References
1 Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors. Toxins (Basel). 2022 Dec 30;15(1):28.