General Information of Binding Target of SBP (BTS) (ID: ST00338)
BTS Name
Coagulation factor IX
Synonyms
EC 3.4.21.22; Christmas factor; Plasma thromboplastin component; PTC
BTS Type
Protein
Family
Peptidase S1 family
Gene Name
F9
Organism
Homo sapiens (Human)
Function
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
UniProt ID
P00740
UniProt Entry
FA9_HUMAN
PFam
PF00008 ; PF00594 ; PF00089
Gene ID
2158
Sequence
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Sequence Length
461
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Megabody anti-FIX Mb-Nb42-cHopQ Research Binder Kd: 337.9 nM Research tool
SBP Info
[1]
Megabody anti-FIX Mb-Nb42-cYgKE2 Research Binder Kd: 445 nM Research tool
SBP Info
[1]
References
1 Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Nat Methods. 2021 Jan;18(1):60-68.