Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00327) | ||||||
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| BTS Name |
Variant surface glycoprotein
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| Synonyms |
VSG, atypical, putative
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| BTS Type |
Protein
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| Organism |
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
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| Function |
VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MNYWIAATGALALAAAITAQGTTLLHNPKAQVTTTCGASHYMRHLTRQAESALERGLTNA
KGALEKSNKLRVVAAYKTGGAATAASILAANLASETAKALETIKTETSNFLEGFTAAAEL AGQQTIVSEIKSAQVQDVNTLTAAQAVTTPGIIQVKPTLAPAATAACFNDDGSPVSDAEA AQPNQGEPTLKFFVVSANTPGTTHNELLTIWGHGSTGTAPSTGCQNEATFIGIKGGDFLK TAAVTTTRLASSAGKTYPAITSTTTIPNDKTLNKAVTAIRKLETAVEALDAISDVSSPED VAARPELKEAIAKALDGDKATYANSATKAKVDSFMAETFGKEPTIVKNTIVKDLKDLKPP KSAVGGNGENKLETINDPKELANAATYYTVKKFVDEQEQKKKNQANRSCPTNTDKTTEPA KSADECKKHTTAKDCKKEAGCDFDDKKPEGERCFPKPETEKKDDKSFSSNVRVSVPHVFA AFAALLF |
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| Sequence Length |
487
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-VSG cAbAn33-1-0-0 | Research | Binder | Kd: 11 nM | Research tool | [1] | |
| Nanobody anti-VSG cAbAn33-1-0-1 | Research | Binder | Kd: 15 nM | Research tool | [1] | |
| Nanobody anti-VSG cAbAn33-1-1-0 | Research | Binder | Kd: 470 nM | Research tool | [1] | |
| Nanobody anti-VSG cAbAn33-1-1-1 | Research | Binder | N.A. | Research tool | [1] | |