Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00279)
BTS Name	Delta-like protein 4
Synonyms	Drosophila Delta homolog 4; Delta4
BTS Type	Protein
Gene Name	DLL4
Organism	Homo sapiens (Human)
Function	Involved in the Notch signaling pathway as Notch ligand Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate
UniProt ID	Q9NR61
UniProt Entry	DLL4_HUMAN
PFam	PF01414 ; PF00008 ; PF07657
Gene ID	54567
Sequence	MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRV CLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIE AWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYY GDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECL CRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATC SNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCE HSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNR GPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTS IDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAV LLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGL DKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICS PRDSMYQSVCLISEERNECVIATEV
Sequence Length	685

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
scFv anti-DLL4 clone 12	Research	Binder	Kd: 141.8 nM	Tools as a reagent with therapeutic potential	SBP Info	[1]
scFv anti-DLL4 clone 3	Research	Binder	Kd: 467.2 nM	Tools as a reagent with therapeutic potential	SBP Info	[1]
scFv anti-DLL4 clone 8	Research	Binder	Kd: 105.6 nM	Tools as a reagent with therapeutic potential	SBP Info	[1]

References

1

Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential. J Mol Biol. 2013 May 27;425(10):1712-30.