Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00249) | ||||||
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| BTS Name |
Renin
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| Synonyms |
EC 3.4.23.15; Angiotensinogenase
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| BTS Type |
Protein
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| Family |
Peptidase A1 family
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| Gene Name |
REN
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| Organism |
Homo sapiens (Human)
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| Function |
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR |
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| Sequence Length |
406
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Peptide aptamer anti-REN clone I-7 | Research | Binder | N.A. | Renin diagnostics | [1] | |
| Peptide aptamer anti-REN clone III-13 | Research | Binder | N.A. | Renin diagnostics | [1] | |
| Peptide aptamer anti-REN clone III-22 | Research | Binder | N.A. | Renin diagnostics | [1] | |