General Information of Binding Target of SBP (BTS) (ID: ST00248)
BTS Name
Cyclin-dependent kinase 1
Synonyms
CDK1; EC 2.7.11.22; EC 2.7.11.23; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase
BTS Type
Protein
Family
Protein kinase superfamily;
CMGC Ser/Thr protein kinase family;
CDC2/CDKX subfamily
Gene Name
Cdk1
Organism
Drosophila melanogaster (Fruit fly)
Function
Plays a key role in the control of the eukaryotic cell cycle It is required in higher cells for entry into S-phase and mitosis In embryos, promotes the release of Rif1 from chromatin during mid-blastula transition p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II
UniProt ID
P23572
UniProt Entry
CDK1_DROME
PFam
PF00069
Gene ID
34411
Sequence
MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKH
ENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCH
RRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPR
YSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNT
FPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVRN
Sequence Length
297
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Peptide aptamer anti-CDK1 Pep8 Research Inhibitor N.A. Eye Defects
SBP Info
[1]
References
1 Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14266-71.