Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00199) | ||||||
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| BTS Name |
WD repeat-containing protein 5
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| Synonyms |
BMP2-induced 3-kb gene protein
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| BTS Type |
Protein
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| Family |
WD repeat WDR5/wds family
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| Gene Name |
WDR5
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| Organism |
Homo sapiens (Human)
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| Function |
Contributes to histone modification May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH TDVVISTACHPTENIIASAALENDKTIKLWKSDC |
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| Sequence Length |
334
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Monobody anti-WDR5 S4 | Research | Inhibitor | Kd: 5 nM | Leukemia [ICD-11: 2B33.4] | [1] | |