General Information of Binding Target of SBP (BTS) (ID: ST00145)
BTS Name
Interleukin-3 receptor subunit alpha
Synonyms
IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD antigen CD123
BTS Type
Protein
Family
Type I cytokine receptor family;
Type 5 subfamily
Gene Name
IL3RA
Organism
Homo sapiens (Human)
Function
This is a receptor for interleukin-3.
UniProt ID
P26951
UniProt Entry
IL3RA_HUMAN
PFam
PF18611 ; PF09240
Gene ID
3563
Sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT
Sequence Length
378
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DART Flotetuzumab Phase II Binder N.A. Acute myeloid leukaemia [ICD-11: XH8AA5]; Myelodysplastic syndrome (MDS) [ICD-11: 2A3Z]
SBP Info
[1], [2]
References
1 Recent advances in the development of novel protein scaffolds based therapeutics. Int J Biol Macromol. 2017 Sep;102:630-641.
2 KEGG DRUG Database. Flotetuzumab