General Information of Binding Target of SBP (BTS) (ID: ST00101)
BTS Name
Low affinity immunoglobulin gamma Fc region receptor II-a
Synonyms
IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD antigen CD32
BTS Type
Protein
Gene Name
FCGR2A
Organism
Homo sapiens (Human)
Function
Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176).
UniProt ID
P12318
UniProt Entry
FCG2A_HUMAN
PFam
PF13895
Gene ID
2212
Sequence
MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTL
TCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVL
SEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHS
HSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIY
CRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDD
KNIYLTLPPNDHVNSNN
Sequence Length
317
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Centyrin anti-Fc-gamma-RII S29 Research Binder N.A. Cancers [ICD-11: 2D4Z]
SBP Info
[1]
References
1 FcRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody. MAbs. 2018 Apr;10(3):463-475.