General Information of Binding Target of SBP (BTS) (ID: ST00096)
BTS Name
Fms-related tyrosine kinase 3 ligand
Synonyms
Flt3 ligand; Flt3L; SL cytokine
BTS Type
Protein
Gene Name
FLT3LG
Organism
Homo sapiens (Human)
Function
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
UniProt ID
P49771
UniProt Entry
FLT3L_HUMAN
PFam
PF02947
Gene ID
2323
Sequence
MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTV
ASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCL
RFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPT
APQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
Sequence Length
235
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
BiTE AMG-427 Phase I Inhibitor N.A. Acute myeloid leukaemia [ICD-11: XH8AA5]
SBP Info
[1], [2]
References
1 Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia. Mol Cancer Ther. 2020 Sep;19(9):1875-1888.
2 Amgen. Product Development Pipeline. 2021.