Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00095) | ||||||
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| BTS Name |
Claudin-18
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| BTS Type |
Protein
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| Family |
Claudin family
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| Gene Name |
CLDN18
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| Organism |
Homo sapiens (Human)
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| Function |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF
TECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI YDGGARTEDEVQSYPSKHDYV |
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| Sequence Length |
261
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| BiTE AMG-910 | Phase I | Stimulator | N.A. | Gastric cancer [ICD-11: 2B72.Z]; Gastroesophageal Junction Cancer [ICD-11: 2B71.Z] | [1] | |