Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00071) | ||||||
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| BTS Name |
Tumor necrosis factor receptor superfamily member 8
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| Synonyms |
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD antigen CD30
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| BTS Type |
Protein
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| Family |
TNFR8 family
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| Gene Name |
TNFRSF8
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for TNFSF8/CD30L May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ
RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK |
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| Sequence Length |
595
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Avibody anti-CD30 AVP10 | Research | Binder | N.A. | Hodgkin lymphoma [ICD-11: 2B30]; Cutaneous Lymphoma [ICD-11: 4A43.0]; Anaplastic large cell lymphoma [ICD-11: XH1LC0] | [1] | |