Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00042) | ||||||
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| BTS Name |
Tumor necrosis factor receptor superfamily member 18
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| Synonyms |
Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD antigen CD357
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| BTS Type |
Protein
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| Gene Name |
TNFRSF18
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| Gene ID | ||||||
| Sequence |
MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRD
YPGEECCSEWDCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTF SGGHEGHCKPWTDCTQFGFLTVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLL TSAQLGLHIWQLRSQCMWPRETQLLLEVPPSTEDARSCQFPEEERGERSAEEKGRLGDLW V |
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| Sequence Length |
241
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Affimer anti-GITR AVA-018 | Research | Agonist | N.A. | Cancers [ICD-11: 2D4Z] | [1] | |