General Information of Binding Target of SBP (BTS) (ID: ST00040)
BTS Name
Alpha-2-antiplasmin
Synonyms
Alpha-2-AP; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2
BTS Type
Protein
Family
Serpin family
Gene Name
SERPINF2
Organism
Homo sapiens (Human)
Function
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
UniProt ID
P08697
UniProt Entry
A2AP_HUMAN
PFam
PF00079
Gene ID
5345
Sequence
MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
EEDYPQFGSPK
Sequence Length
491
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affimer anti-Alpha-2-AP AVA-016 Research Binder N.A. Bleeding disorders [ICD-11: GA21]
SBP Info
[1]
References
1 Avacta. Product Development Pipeline. 2021.