General Information of Binding Target of SBP (BTS) (ID: ST00024)
BTS Name
Major surface glycoprotein G
Synonyms
Attachment glycoprotein G; Membrane-bound glycoprotein; mG
BTS Type
Protein
Family
Pneumoviruses glycoprotein G family
Gene Name
G
Organism
Human respiratory syncytial virus A (strain A2)
Function
[Isoform Membrane-bound glycoprotein G]: Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).; [Isoform Secreted glycoprotein G]: Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
UniProt ID
P03423
UniProt Entry
GLYC_HRSVA
PFam
PF00802
Sequence
MSKNKDQRTAKTLERTWDTLNHLLFISSCLYKLNLKSVAQITLSILAMIISTSLIIAAII
FIASANHKVTPTTAIIQDATSQIKNTTPTYLTQNPQLGISPSNPSEITSQITTILASTTP
GVKSTLQSTTVKTKNTTTTQTQPSKPTTKQRQNKPPSKPNNDFHFEVFNFVPCSICSNNP
TCWAICKRIPNKKPGKKTTTKPTKKPTLKTTKKDPKPQTTKSKEVPTTKPTEEPTINTTK
TNIITTLLTSNTTGNPELTSQMETFHSTSSEGNPSPSQVSTTSEYPSQPSSPPNTPRQ
Sequence Length
298
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affibody anti-Glycoprotein-G Z(RSV1) Research Binder Kd: 1000 nM Diagnostic reagent; Therapeutic application
SBP Info
[1]
References
1 An in vitro selected binding protein (affibody) shows conformation-dependent recognition of the respiratory syncytial virus (RSV) G protein. Immunotechnology. 1999 Mar;4(3-4):237-52.